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Antenatal creatine supplementation reduces persistent fetal lung inflammation and oxidative stress in an ovine model of chorioamnionitis

Chorioamnionitis is a common antecedent of preterm birth and induces inflammation and oxidative stress in the fetal lungs. Reducing inflammation and oxidative stress in the fetal lungs may improve respiratory outcomes in preterm infants. Creatine is an organic acid with known anti-inflammatory and antioxidant properties.

Surveillance of avian influenza through bird guano in remote regions of the global south to uncover transmission dynamics

Avian influenza viruses (AIVs) pose a growing global health threat, particularly in low- and middle-income countries (LMICs), where limited surveillance capacity and under-resourced healthcare systems hinder timely detection and response. Migratory birds play a significant role in the transboundary spread of AIVs, yet data from key regions along migratory flyways remain sparse. To address these surveillance gaps, we conducted a study between December 2021 and February 2023 using fresh bird guano collected across 10 countries in the Global South.

ORIGIN-1 trial: study protocol for an organoid-guided N-of-1 trial evaluating CFTR modulator response in cystic fibrosis with rare non-F508del mutations

Cystic fibrosis (CF) is a genetic condition caused by mutation of the cystic fibrosis transmembrane regulator (CFTR) gene. Recently licensed modulator therapies target the defective CFTR protein and have transformed the formerly life-limiting trajectory of people with CF (pwCF).

Corrigendum to: “COVID-19 monitoring with sparse sampling of sewered and non-sewered wastewater in urban and rural communities” [iScience, Volume 26, Issue 7 (2023) 107019]

Anthony Kicic BSc (Hons) PhD Head, Airway Epithelial Research; WA Cystic Fibrosis Research Collaborative Program Fellowship; Stan Perron Charitable Foundation Research Fellow Anthony.Kicic@thekids.org.au Rothwell Family Fellow; Head, Airway

First global synthesis of heat-related mental health impacts in children and young people: a systematic review and meta-analysis

Climate change is increasing the frequency and severity of non-optimal temperatures and heatwaves, posing risks to public health, especially for children and young people. We performed a systematic review and meta-analysis to assess the impacts of (i) non-optimal ambient temperatures and (ii) heatwaves on mental health outcomes in this group globally.