Rhinovirus Infection Is Associated With Airway Epithelial Cell Necrosis and Inflammation via Interleukin-1 in Young Children With Cystic Fibrosis

Rhinovirus is the most common infection early in life for young children with cystic fibrosis, and it drives pulmonary exacerbation which can permanently affect lung function. We have previously identified specific inflammatory signalling present in the CF airway can be induced by rhinovirus infectin, and thus can be targeted by translation of currently approved drugs in other diseases to target inflammation following infection.

Authors: Samuel T. Montgomery, Dario L. Frey, Marcus A. Mall, Stephen M. Stick and Anthony Kicic on behalf of the WA Epithelial Research Program (WAERP) and AREST CF